Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines
نویسندگان
چکیده
منابع مشابه
Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملTopical Tretinoin and 5-Fluorouracil in treatment of epidermal nevus
Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirm...
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملThe antineoplastic and biochemical effects of some 5-fluoropyrimidines.
5-fluoropyrimidine (2-HFP) were measured on Sarcoma 180 ascites cells. A marked extension of the life-span of tumor-bearing mice was afforded by i.p. injections of 5-FU, whereas both 4-HFP and 2-HFP were only weakly active. Sarcoma 180 ascites cells converted both 4-HFP and 5-FU into mono-, di-, and trinucleotide forms of 5-FU and incorporated the 5-fluoropyrimidines into RNA exclusively as 5-F...
متن کاملToxicity of 5-fluorouracil.
Fluorouracil (5-FU) is a relatively unique drug in oncology because administration in different doses and schedules results in dramatically different patterns of qualitative toxicity. In the 41 years 5-FU has been available to the clinical oncologist, a wide variety of doses and schedules of this agent have been used. Infusional schedules are associated with less myelosuppression but may have m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Treatment Options in Oncology
سال: 2020
ISSN: 1527-2729,1534-6277
DOI: 10.1007/s11864-020-0719-1